Flybe expands Bristol Airport services
The company has also revealed plans to expand its route to Jersey in a bid to boost domestic tourism.
Flybe said the new services would be affordable and will give people the opportunity to "travel in style".
Shaun Browne, aviation director at Bristol Airport, said: "We are delighted that Flybe will be operating additional flights from Bristol International and we look forward to working together to ensure the success of these and other potential routes in future."
The new Isle of Man route will take just over an hour, flying on Tuesday, Thursday and Sunday.
A Saturday service will also be added between May and September.
People who prefer to head abroad for their holiday can catch flights from Bristol Airport to many ski holiday destinations, with the hub launching its first ski flight of the winter 2009-10 season on December 6th.